An enzyme-responsive metal-enhanced near-infrared fluorescence sensor based on functionalized gold nanoparticles

Metal-Enhanced Near-Infrared Fluorescence by Micropatterned Gold Nanocages

In metal-enhanced fluorescence (MEF), the localized surface plasmon resonances of metallic nanostructures amplify the absorption of excitation light and assist in radiating the consequent fluorescence of nearby molecules to the far-field. This effect is at the base of various technologies that have strong impact on fields such as optics, medical diagnostics, and biotechnology. Among possible em...

Near-Infrared Surface-Enhanced Fluorescence Using Silver Nanoparticles in Solution

An enzyme-responsive metal-enhanced near-infrared fluorescence sensor based on functionalized gold nanoparticles† †Electronic supplementary information (ESI) available: Detailed information on the synthetic routes to various ligands, characterization data, additional figures, schemes, tables and general experiment procedures are provided. See DOI: 10.1039/c5sc01850a Click here for additional data file.

Near-infrared (NIR) fluorescence imaging is promising due to the high penetration depths and minimal levels of autofluorescence in living systems. However, it suffers from low fluorescent quantum yield, and metal-enhanced fluorescence (MEF) is considered to be a promising technique to overcome this. Stimuli-responsive NIR fluorescence enhancement shows remarkable potential for applications in m...

Multiplexed cytokine detection on plasmonic gold substrates with enhanced near-infrared fluorescence

Protein microarrays based on fluorescence detection have been widely utilized for high-throughput functional proteomic analysis. However, a drawback of such assays has been low sensitivity and narrow dynamic range, limiting their capabilities especially for detecting low abundance biological molecules such as cytokines in human samples. Here, we present fluorescence-enhanced microarrays by plas...

Near-Infrared Fluorescence-Enhanced Optical Tomography

Fluorescence-enhanced optical imaging using near-infrared (NIR) light developed for in vivo molecular targeting and reporting of cancer provides promising opportunities for diagnostic imaging. The current state of the art of NIR fluorescence-enhanced optical tomography is reviewed in the context of the principle of fluorescence, the different measurement schemes employed, and the mathematical t...